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Science, Technology and Development Vol. 37 (2), 2018
Research Article
Toxic Effects of Plant Mediated Silver Nanoparticles on Human Cancer Cell Lines and Bacteria
Wasim Ahmad, Mushtaq Ahmad, Rahmat Ali Khan and Nadia Mushtaq
 
Abstract: In pharmaceutical industry, plant mediated nanoparticles, predominantly silver nanoparticles (SNPs) are extensively under consideration for the production of novel drugs. These plant mediated nanoparticles do not harm the nature and therefore, their synthesis is called “Green Synthesis”. In the current study, toxic effects of plant mediated SNPs were appraised against human cancer cell lines and bacteria.
Synthesis of stable silver nanoparticles was done by mixing AgNO3 solution (aq) with Salix nigra extract as a reducing agent. The extract was intermixed with reagent AgNO3, incubated and studied for the biosynthesis of nanoparticles. Confirmation of synthesis was done by observing color change of plant extracts (SNPs) and UV-Vis spectroscopy. Characterization was done by FTIR, DLS, XRD and SEM. Furthermore, these nanoparticles were tested for their toxic effects on human cancer cell lines and bacteria.
Results against cancer cell lines presented meaningful anti-cell proliferation outcome in smaller concentrations (nano-molar). The antibacterial potential of nanoparticles was investigated by determining the inhibition zone.
Our findings showed that the extract of Salix nigra was a very righteous bioreductant and capping agent for the synthesis of silver nanoparticles which, in turn, showed a good toxic activity against human cancer cell lines and clinically inaccessible human pathogens. Thus, the results of this study would be helpful in formulating value added herbal based drugs in biomedical industries.
 
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